Structure, synthesis, and biosynthesis of fumonisin B1 and related compounds.
نویسنده
چکیده
The absolute stereochemical description of fumonisin B1 (FB1) and presumably of its congeners is now secure. In this article I summarize studies leading to this conclusion and outline the biosynthetic and synthetic studies of FB1.
منابع مشابه
Total synthesis of the sphingolipid biosynthesis inhibitor fumonisin B(1).
The first total synthesis of the sphingolipid biosynthesis inhibitor fumonisin B(1) has been achieved. This convergent synthesis utilizes oxonia Cope rearrangements to prepare two key homoallylic alcohols, which are then functionalized to the primary components A and B for cross-coupling. Other highlights of our approach include a new and efficient synthesis of the diprotected tricarballylic ac...
متن کاملSurvey of fumonisin B1 contamination of cornin Northern Iran during 2000
Fumonisin B1 (FB1) is the most abundant of the fumonisin mycotoxins, mainly produced in corn by fungi of the genus Fusarium. FB1 has been shown to be hepatocarcinogenic and nephrocarcinogenic in animals. Contamination of corn with FB1 was assayed in samples collected from Mazandaran Province, situated on the Caspian littoral of Iran, in September 2000. In this survey, 38 corn samples were analy...
متن کاملDe novo ceramide synthesis is required for N-linked glycosylation in plasma cells.
Plasma cells (PCs) are terminally differentiated B lymphocytes responsible for the synthesis and secretion of Igs. The differentiation of B cells into PCs involves a remarkable expansion of both lipid and protein components of the endoplasmic reticulum. Despite their importance in many signal transduction pathways, the role of ceramides, and of complex sphingolipids that are derived from cerami...
متن کاملSerum Biochemistry, Lipid and Pathology Alterations in Sinclair Minipigs Fed Low Levels of Fumonisin B1 for Six Months. Introduction Fumonisins are a group of naturally occurring mycotoxins produced by the fungus Fusarium verticillioides
Fumonisins are a group of naturally occurring mycotoxins produced by the fungus Fusarium verticillioides (previously moniliforme). Fumonisin B1 (FB1), is the most common toxin produced. Fumonisins alter sphingolipid biosynthesis, induce hepatotoxicity, and elevate serum cholesterol concentration in all species studied including pigs, calves, lambs, mice, rats, mink, and broiler chicks. A major ...
متن کاملEthylene Modulates Sphingolipid Synthesis in Arabidopsis
Sphingolipids have essential structural and bioactive functions in membranes and in signaling. However, how plants regulate sphingolipid biosynthesis in the response to stress remains unclear. Here, we reveal that the plant hormone ethylene can modulate sphingolipid synthesis. The fungal toxin Fumonisin B1 (FB1) inhibits the activity of ceramide synthases, perturbing sphingolipid homeostasis, a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 109 شماره
صفحات -
تاریخ انتشار 2001